Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.

PloS one - 1 Jan 2012

Brattelid Trond, Qvigstad Eirik, Moltzau Lise R, Bekkevold Silje V S, Sandnes Dagny L, Birkeland Jon Arne K, Skomedal Tor, Osnes Jan-Bjørn, Sjaastad Ivar, Levy Finn Olav

Abstract excerpt

A positive inotropic responsiveness to serotonin, mediated by 5-HT(4) and 5-HT(2A) receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A hallmark of HF is a transition towards a foetal genotype which correlates with loss of cardiac functions. Thus, we wanted to investigate whether the foetal and neonatal cardiac ventricle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fetal Development
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Failure

Share to Heart Ventricles

Share to Myocardial Contraction

Share to Pregnancy

Share to Receptors, Adrenergic, beta

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23029047
DOI: 10.1371/journal.pone.0045489
PMCID: PMC3447799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.PMID 23029047Read ↗

Fetal-adult cardiac transcriptome analysis in rats with contrasting left ventricular mass reveals new candidates for cardiac hypertrophy.Semantic proximity Read ↗

Functional Consequence of Serotonin/5-HT 2B Receptor Signaling in HeartSemantic proximity Read ↗

Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/RegenerationSemantic proximity Read ↗

[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].Semantic proximity Read ↗

Serotonin 2B receptor is required for heart developmentSemantic proximity Read ↗

Developmentally regulated serotonin 5‐HT<sub>2B</sub> receptorsSemantic proximity Read ↗

[Serotonin and the cardiovascular system: role of the serotoninergic 5-HT 2B receptor].Semantic proximity Read ↗

Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Semantic proximity Read ↗

Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.Semantic proximity Read ↗

Thyroid hormone receptor alpha 1: a switch to cardiac cell "metamorphosis"?Semantic proximity Read ↗

Serotonin transporter deficiency in mice results in an increased susceptibility to HTR2B-dependent pro-fibrotic mechanisms in the cardiac valves and left ventricular myocardium.Semantic proximity Read ↗

Maternal serotonin is crucial for murine embryonic development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.