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Article

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.

PloS one - 1 Jan 2012

Brattelid Trond, Qvigstad Eirik, Moltzau Lise R, Bekkevold Silje V S, Sandnes Dagny L, Birkeland Jon Arne K, Skomedal Tor, Osnes Jan-Bjørn, Sjaastad Ivar, Levy Finn Olav

Abstract excerpt

A positive inotropic responsiveness to serotonin, mediated by 5-HT(4) and 5-HT(2A) receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A hallmark of HF is a transition towards a foetal genotype which correlates...

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Share to Fetal Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, beta

Share to Serotonin Plasma Membrane Transport Proteins

Source

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Identifiers

PMID: 23029047
DOI: 10.1371/journal.pone.0045489
PMCID: PMC3447799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23029047-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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