Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis.

The Journal of biological chemistry - 17 Nov 2000

Yamamura Y, Hua X, Bergelson S, Lodish H F

Abstract excerpt

Transforming growth factor-beta1 (TGF-beta1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Although Smad proteins are identified as key signal transducers in TGF-beta1-dependent growth inhibition, their roles in the induction of apoptosis are unclear. We show here that both Smad proteins and AP-1 complex are involved in TGF-beta1 signaling for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proto-Oncogene Proteins c-fos
Share to Proto-Oncogene Proteins c-jun

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Response Elements

Share to Smad3 Protein

Share to Smad4 Protein

Share to Smad7 Protein

Share to Transcription Factor AP-1

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 10942775
DOI: 10.1074/jbc.M006023200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis.PMID 10942775Read ↗

Identification of the gene transcription and apoptosis mediated by TGF‐β‐Smad2/3‐Smad4 signalingSemantic proximity Read ↗

Regulation of cell proliferation by Smad proteins.Semantic proximity Read ↗

Transforming growth factor-beta-mediated tumor necrosis factor-related apoptosis-inducing ligand expression and apoptosis in hepatoma cells requires functional cooperation between Smad proteins and activator protein-1.Semantic proximity Read ↗

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activationSemantic proximity Read ↗

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcriptionSemantic proximity Read ↗

A transcriptionally active pRb–E2F1–P/CAF signaling pathway is central to TGFβ-mediated apoptosisSemantic proximity Read ↗

Smads bind directly to the Jun family of AP-1 transcription factorsSemantic proximity Read ↗

TGFβ1-Induced Activation of ATM and p53 Mediates Apoptosis in a Smad7-Dependent MannerSemantic proximity Read ↗

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated TranscriptionSemantic proximity Read ↗

Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific mannerSemantic proximity Read ↗

Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor.Semantic proximity Read ↗

Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.