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Article

Mutation analysis of the hMTH1 gene in sporadic human ovarian cancer.

International journal of oncology - 1 Sept 2000

Takama F, Kanuma T, Wang D, Nishida J I, Nakabeppu Y, Wake N, Mizunuma H

Abstract excerpt

8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) is a major oxidation product in the nucleotide pool of the cell and is a potent mutagen, because it can be incorporated into DNA with equal frequency opposite either template C or A. The human MTH1 gene (hMTH1) is a homologue of the E. coli mutator gene mutT, which encodes 8-oxo-dGTPase. hMTH1 protein reduces spontaneous mutations by removing 8-oxo-dGTP from the...

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Identifiers

PMID: 10938385
DOI: 10.3892/ijo.17.3.467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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