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Optimized DNA electroporation for primary human T cell engineering

30 Jan 2018

Abstract excerpt

BACKGROUND: Effective gene-delivery systems for primary human T cell engineering are useful tools for both basic research and clinical immunotherapy applications. Pseudovirus-based systems and electro-transfection are the most popular strategies for genetic material transduction. Compared with viral-particle-mediated approaches, electro-transfection is theoretically safer, because it does not promote transgene...

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PMID: 29378552
DOI: 10.1186/s12896-018-0419-0

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