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Optimization of electroporation and other non‐viral gene delivery strategies for T cells

28 Aug 2020

Abstract excerpt

Abstract CAR‐T therapy is a particularly effective treatment for some types of cancer that uses retroviruses to deliver the gene for a chimeric antigen receptor (CAR) to a patient's T cells ex vivo. The CAR enables the T cells to bind and eradicate cells with a specific surface marker (e.g., CD19 + B cells) after they are transfused back into the patient. This treatment was proven to be particularly effective in...

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PMID: 32808434
DOI: 10.1002/btpr.3066

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