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Article

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

Nature structural biology - 1 Aug 2000

Sharma V, Sharma S, Hoener zu Bentrup K, McKinney J D, Russell D G, Jacobs W R, Sacchettini J C

Abstract excerpt

Isocitrate lyase (ICL) plays a pivotal role in the persistence of Mycobacterium tuberculosis in mice by sustaining intracellular infection in inflammatory macrophages. The enzyme allows net carbon gain by diverting acetyl-CoA from beta-oxidation of fatty acids into the glyoxylate shunt pathway. Given its potential as a drug target against persistent infections, we solved its structure without ligand and in...

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Identifiers

PMID: 10932251
DOI: 10.1038/77964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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