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Article

Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis.

Scientific reports - 21 Mar 2017

Bi Jing, Wang Yihong, Yu Heguo, Qian Xiaoyan, Wang Honghai, Liu Jun, Zhang Xuelian

Abstract excerpt

Several enzymes involved in central carbon metabolism such as isocitrate lyase and phosphoenolpyruvate carboxykinase are key determinants of pathogenesis of Mycobacterium tuberculosis (M. tb). In this study, we found that lysine acetylation plays an important role in the modulation of central carbon metabolism in M. tb. Mutant of M. tb defective in sirtuin deacetylase exhibited improved growth in fatty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28322251
DOI: 10.1038/srep44826
PMCID: PMC5359664

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