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Article

Cell size and the initiation of DNA replication in bacteria.

PLoS genetics - 1 Jan 2012

Hill Norbert S, Kadoya Ryosuke, Chattoraj Dhruba K, Levin Petra Anne

Abstract excerpt

In eukaryotes, DNA replication is coupled to the cell cycle through the actions of cyclin-dependent kinases and associated factors. In bacteria, the prevailing view, based primarily from work in Escherichia coli, is that growth-dependent accumulation of the highly conserved initiator, DnaA, triggers initiation. However, the timing of initiation is unchanged in Bacillus subtilis mutants that are ~30% smaller than...

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Identifiers

PMID: 22396664
DOI: 10.1371/journal.pgen.1002549
PMCID: PMC3291569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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