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Article

Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein.

Circulation research - 4 Aug 2000

Zeidan A, Nordström I, Dreja K, Malmqvist U, Hellstrand P

Abstract excerpt

Increased intraluminal pressure of the rat portal vein in vivo causes hypertrophy and altered contractility in 1 to 7 days. We have used organ cultures to investigate mechanisms involved in this adaptation to mechanical load. Strips of rat portal vein were cultured for 3 days, either undistended or loaded by a weight. Length-force relations were shifted toward longer length in stretched cultured veins compared...

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Identifiers

PMID: 10926874
DOI: 10.1161/01.res.87.3.228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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