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Article

BMP signaling is required for heart formation in vertebrates.

Developmental biology - 15 Aug 2000

Shi Y, Katsev S, Cai C, Evans S

Abstract excerpt

In these studies, we have taken advantage of a transient transgenic strategy in Xenopus embryos to demonstrate that BMP signaling is required in vivo for heart formation in vertebrates. Ectopic expression of dominant negative Type I (tALK3) or Type II (tBMPRII) BMP receptors in developing Xenopus embryos results in reduction or absence of heart formation. Additionally, blocking BMP signaling in this manner...

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Identifiers

PMID: 10926762
DOI: 10.1006/dbio.2000.9802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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