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Article

Chemically regulated zinc finger transcription factors.

The Journal of biological chemistry - 20 Oct 2000

Beerli R R, Schopfer U, Dreier B, Barbas C F

Abstract excerpt

Ligand-dependent transcriptional regulators were generated by fusion of designed Cys(2)-His(2) zinc finger proteins and steroid hormone receptor ligand binding domains. To produce novel DNA binding domains, three-finger proteins binding specific 9-base pair sequences were constructed from modular building blocks. Fusion of these zinc finger proteins to a transcriptional activation domain and to modified ligand...

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Identifiers

PMID: 10924515
DOI: 10.1074/jbc.M005108200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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