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Article

The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast.

Genetics - 1 Aug 2000

Ireland M J, Reinke S S, Livingston D M

Abstract excerpt

We have examined the stability of long tracts of CAG repeats in yeast mutants defective in enzymes suspected to be involved in lagging strand replication. Alleles of DNA ligase (cdc9-1 and cdc9-2) destabilize CAG tracts in the stable tract orientation, i.e., when CAG serves as the lagging strand template. In this orientation nearly two-thirds of the events recorded in the cdc9-1 mutant were tract expansions....

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Identifiers

PMID: 10924464
DOI: 10.1093/genetics/155.4.1657
PMCID: PMC1461208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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