CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair.

Abstract excerpt

Mechanisms contributing to disease-associated trinucleotide repeat instability are poorly understood. DNA ligation is an essential step common to replication and repair, both potential sources of repeat instability. Using derivatives of DNA ligase I (hLigI)-deficient human cells (46BR.1G1), we as...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blotting, Western
• Share to Cell Cycle
• Share to DNA Ligase ATP