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Article

Malignant hyperthermia mutation Arg615Cys in the porcine ryanodine receptor alters voltage dependence of Ca2+ release.

The Journal of physiology - 1 Aug 2000

Dietze B, Henke J, Eichinger H M, Lehmann-Horn F, Melzer W

Abstract excerpt

Ca2+ inward current and fura-2 Ca2+ transients were simultaneously recorded in porcine myotubes. Myotubes from normal pigs and cells from specimens homozygous for the Arg615Cys (malignant hyperthermia) mutation of the skeletal muscle ryanodine receptor RyR1 were investigated. We addressed the question whether this mutation alters the voltage dependence of Ca2+ release from the sarcoplasmic reticulum. The time...

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Identifiers

PMID: 10922003
DOI: 10.1111/j.1469-7793.2000.t01-1-00507.x
PMCID: PMC2270038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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