Article
Cytoplasmic dynein ATPase activity is regulated by dynactin-dependent phosphorylation.
The Journal of biological chemistry - 13 Oct 2000
Kumar S, Lee I H, Plamann M
Abstract excerpt
Cytoplasmic dynein is a microtubule-associated motor that utilizes ATP hydrolysis to conduct minus-end directed transport of various organelles. Dynactin is a multisubunit complex that has been proposed to both link dynein with cargo and activate dynein motor function. The mechanisms by which dynactin regulates dynein activity are not clear. In this study, we examine the role of dynactin in regulating dynein...
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