Article
A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration.
Cell - 26 Aug 1994
Muhua L, Karpova T S, Cooper J A
Abstract excerpt
Spindle orientation controls nuclear migration and segregation during mitosis. In yeast, defects in dynein and astral microtubules lead to abnormal spindle orientation and nuclear migration. Dynactin complex is necessary for dynein-mediated vesicle motility in vitro. The major polypeptide of dyna...
Topics
- Actins
- Amino Acid Sequence
- Base Sequence
- Cell Nucleus
- Cytoskeletal Proteins
- Dynactin Complex
- Dyneins
- Fungal Proteins
- Genes, Fungal
- Microtubule Proteins
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutation
- Phylogeny
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Alignment
- Sequence Analysis, DNA