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Article

Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2000

Futaki S, Takagishi Y, Hayashi Y, Ohmori S, Kanou Y, Inouye M, Oda S, Seo H, Iwaikawa Y, Murata Y

Abstract excerpt

Mutations of the myosin-Va gene (Myo5a) cause diluted coat color in mice and are occasionally associated with severe neurological disorders. Dilute-opisthotonus (dop) is a spontaneous gene mutation in the rat, and phenotypes of the homozygote (dop/dop) are similar to those of the Myo5a-deficient mouse, suggesting that the mutation resides in the rat Myo5a gene. To elucidate the molecular basis of the dop...

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PMID: 10920234
DOI: 10.1007/s003350010121

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