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Article

Myosin Va mutation in rats is an animal model for the human hereditary neurological disease, Griscelli syndrome type 1.

Annals of the New York Academy of Sciences - 1 Nov 2006

Takagishi Yoshiko, Murata Yoshiharu

Abstract excerpt

A spontaneous neurological mutation, dilute-opisthotonus (dop), was discovered in our breeding colony of Wistar rats. We found that the mutation affected the gene encoding Myosin Va (MyoVA), an actin-based molecular motor. Analysis of the myosin Va (Myo5a) gene of the dop genome showed the presence of a complex rearrangement consisting of a 306-bp inversion associated with 217-bp and 17-bp deletions. A 141-bp...

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PMID: 17185506
DOI: 10.1196/annals.1377.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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