Article
Anthrax toxin-mediated delivery of cholera toxin-A subunit into the cytosol of mammalian cells.
Biotechnology and applied biochemistry - 1 Aug 2000
Sharma M, Khanna H, Arora N, Singh Y
Abstract excerpt
The protective antigen (PA) component of anthrax toxin mediates delivery of either lethal factor (LF) or oedema factor into the cytosol of mammalian cells. The N-terminal domain of LF(1-254) (amino acids 1-254 of LF) binds to PA and, when fused to heterologous proteins, delivers such proteins into the cytosol. In the present study, we fused the catalytic subunit of cholera toxin (CT-A) with LF(1-254) and showed...
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