Article
Type 1 diabetes and prediabetic state in a monozygotic triplet.
Acta geneticae medicae et gemellologiae - 1 Jan 1998
Krokowski M, Abel M, Teodorczyk A, Szadkowska A, Pyrzak B, Rymkiewicz-Kluczyńska B, Bodalski J
Abstract excerpt
Type 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of beta cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum precedes the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region. The aim of the study was the genetic and immunological analysis of a triplet. One of them...
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