In vitro evolution provides insights into mechanisms of Mycoplasma genitalium resistance to moxifloxacin.

doi:10.1093/jac/dkaf324

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Article

In vitro evolution provides insights into mechanisms of Mycoplasma genitalium resistance to moxifloxacin.

The Journal of antimicrobial chemotherapy - 4 Nov 2025

Chua Teck-Phui, Huaman Jose L, Danielewski Jennifer, Bradshaw Catriona S, Machalek Dorothy A, McDonald Michael J, Garland Suzanne M, Murray Gerald L

Abstract excerpt

BACKGROUND: Current knowledge of Mycoplasma genitalium fluoroquinolone resistance is based on sequence analyses of clinical samples, an approach with limited scope. Many potential resistance mutations have been described but their impact on moxifloxacin efficacy is unclear. OBJECTIVE: To investigate the impact of individual mutations on fluoroquinolone resistance through selection of moxifloxacin-resistant...

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Topics

Moxifloxacin
Fluoroquinolones
Mycoplasma genitalium
Microbial Sensitivity Tests
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Bacterial

Humans

DNA Gyrase

DNA Topoisomerase IV

Mutation

Serial Passage

Evolution, Molecular

Selection, Genetic

Source

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Identifiers

PMID: 40971933
DOI: 10.1093/jac/dkaf324
PMCID: PMC12596053

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