Article
Absence of somatic RET gene mutation in sporadic parathyroid tumors and hyperplasia secondary to uremia, and absence of somatic Men1 gene mutation in MEN2A-associated hyperplasia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jun 2000
Uchino S, Noguchi S, Nagatomo M, Sato M, Yamashita H, Yamashita H, Watanabe S, Murakami T, Toda M, Wakiya S, Adachi M
Abstract excerpt
Germline mutations of the MEN1 gene are found in more than 85% of multiple endocrine neoplasia type 1 (MEN 1) patients, and germline mutations of the RET gene are found in more than 95% of multiple endocrine neoplasia type 2 (MEN2) patients. Parathyroid hyperplasia is seen in more than 90% of MEN 1 and about 15% of MEN2A patients. To date, somatic MEN1 mutations are reported in about 20% of sporadic parathyroid...
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