Article
The genetic background of uremic secondary hyperparathyroidism.
Journal of nephrology - 1 Jan 2000
Aucella Filippo, Morrone Luigi, Stallone Carmine, Gesualdo Loreto
Abstract excerpt
Many studies have shown how gene mutations and genetic polymorphisms could influence secondary uremic hyperparathyroidism (HPTH), modulating parathyroid (PT) function and hyperplasia. Parathyroid hormone (PTH) gene expression and hormone secretion is regulated mainly by serum calcium, with a post-transcriptional effect, and by vitamin D with a transcriptional effect. PT cells retain the ability to proliferate and...
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