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Article

Clonal chromosomal defects in the molecular pathogenesis of refractory hyperparathyroidism of uremia.

Journal of the American Society of Nephrology : JASN - 1 Jun 2002

Imanishi Yasuo, Tahara Hideki, Palanisamy Nallasivam, Spitalny Sarah, Salusky Isidro B, Goodman William, Brandi Maria Luisa, Drüeke Tilman B, Sarfati Emile, Ureña Pablo, Chaganti R S K, Arnold Andrew

Abstract excerpt

Indirect X chromosome-inactivation analyses have demonstrated that most parathyroid glands from patients with uremic refractory secondary/tertiary hyperparathyroidism are monoclonal neoplasms. However, little is known regarding the specific acquired genetic abnormalities that must underlie such clonal expansion or the molecular pathogenetic features of this disorder, compared with primary parathyroid adenomas. To...

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Source

Identifiers

PMID: 12039978
DOI: 10.1097/01.asn.0000018148.50109.c0

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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