Article
Immunophenotypic discrepancies between granulocytic and erythroid lineages in peripheral blood of patients with paroxysmal nocturnal haemoglobinuria.
European journal of haematology - 1 Jul 2000
Pakdeesuwan K, Wanachiwanawin W, Siripanyaphinyo U, Pattanapanyasat K, Wilairat P, Issaragrisil S
Abstract excerpt
In paroxysmal nocturnal haemoglobinuria (PNH), somatic mutation of the PIG-A gene is thought to result in altered expression of glycosylphosphatidylinositol (GPI)-anchored proteins. This study was performed to determine if there were any heterogeneities of cellular phenotypes between two major peripheral blood cells, erythrocytes and granulocytes. Using CD59-based immunocytometry, the patterns of CD59 expression...
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