Article
The distribution of PIG-A gene abnormalities in paroxysmal nocturnal hemoglobinuria granulocytes and cultured erythroblasts.
Experimental hematology - 1 Apr 2001
Noji H, Shichishima T, Saitoh Y, Kai T, Yamamoto T, Ogawa K, Okamoto M, Ikeda K, Maruyama Y
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia that is characterized by a deficiency of glycosylphosphatidylinositol-anchored membrane proteins due to phosphatidylinositol glycan-class A (PIG-A) gene abnormalities in various lineages of peripheral blood cells and hematopoietic precursors. The purpose of our study was to clarify the distribution of PIG-A gene abnormalities among various...
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