Article
Detailed immunophenotypic characterization of different major and minor subsets of peripheral blood cells in patients with paroxysmal nocturnal hemoglobinuria.
Transfusion - 1 Jul 2008
Hernández-Campo Pilar M, Almeida Julia, Acevedo María J, Sánchez María L, Alberca Ignacio, Vidriales Belén, Martínez Elvira, Romero Juan R, Orfao Alberto
Abstract excerpt
BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by a deficient expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs), due to somatic mutations of the phosphatidylinositolglycan complementation Class A (PIG-A) gene. STUDY DESIGN AND METHODS: In this study, the expression of a high number of GPI-APs on different subsets of peripheral blood (PB) cells from 14 PNH patients and...
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