Article
Defining TCRγδ lymphoproliferative disorders by combined immunophenotypic and molecular evaluation.
Nature communications - 8 Jun 2022
Teramo Antonella, Binatti Andrea, Ciabatti Elena, Schiavoni Gianluca, Tarrini Giulia, Barilà Gregorio, Calabretto Giulia, Vicenzetto Cristina, Gasparini Vanessa Rebecca, Facco Monica, Petrini Iacopo, Grossi Roberto, Pisanti Nadia, Bortoluzzi Stefania, Falini Brunangelo, Tiacci Enrico, Galimberti Sara, Semenzato Gianpietro, Zambello Renato
Abstract excerpt
Tγδ large granular lymphocyte leukemia (Tγδ LGLL) is a rare lymphoproliferative disease, scantily described in literature. A deep-analysis, in an initial cohort of 9 Tγδ LGLL compared to 23 healthy controls, shows that Tγδ LGLL dominant clonotypes are mainly public and exhibit different V-(D)-J γ/δ usage between patients with symptomatic and indolent Tγδ neoplasm. Moreover, some clonotypes share the same...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.