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Article

Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation.

Molecular and cellular biology - 1 Aug 2000

Tabb M M, Tongaonkar P, Vu L, Nomura M

Abstract excerpt

Srp1p (importin alpha) functions as the nuclear localization signal (NLS) receptor in Saccharomyces cerevisiae. The srp1-31 mutant is defective in this nuclear localization function, whereas an srp1-49 mutant exhibits defects that are unrelated to this localization function, as was confirmed by intragenic complementation between the two mutants. RPN11 and STS1 (DBF8) were identified as high-dosage suppressors of...

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Identifiers

PMID: 10913188
DOI: 10.1128/MCB.20.16.6062-6073.2000
PMCID: PMC86082

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation.PMID 10913188Read ↗

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