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Article

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

The Journal of cell biology - 1 Aug 1994

Belanger K D, Kenna M A, Wei S, Davis L I

Abstract excerpt

Nup1p is a yeast nuclear pore complex protein (nucleoporin) required for nuclear protein import, mRNA export and maintenance of normal nuclear architecture. We have used a genetic approach to identify other proteins that interact functionally with Nup1p. Here we describe the isolation of seventeen mutants that confer a requirement for Nup1p in a background in which this protein is normally not essential. Some of...

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Identifiers

PMID: 8045927
DOI: 10.1083/jcb.126.3.619
PMCID: PMC2120133

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Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.PMID 8045927Read ↗

The NUP1 gene encodes an essential component of the yeast nuclear pore complex.Semantic proximity Read ↗

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.Semantic proximity Read ↗

Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.Semantic proximity Read ↗

ER membrane-bending proteins are necessary for de novo nuclear pore formation.Semantic proximity Read ↗

The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.Semantic proximity Read ↗

Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex.Semantic proximity Read ↗

Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.Semantic proximity Read ↗

Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.Semantic proximity Read ↗

The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function.Semantic proximity Read ↗

Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.Semantic proximity Read ↗

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