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Article

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

The Journal of cell biology - 1 Aug 1994

Belanger K D, Kenna M A, Wei S, Davis L I

Abstract excerpt

Nup1p is a yeast nuclear pore complex protein (nucleoporin) required for nuclear protein import, mRNA export and maintenance of normal nuclear architecture. We have used a genetic approach to identify other proteins that interact functionally with Nup1p. Here we describe the isolation of seventee...

Topics

Alleles
Base Sequence
Cloning, Molecular
Genes, Lethal
Genetic Complementation Test
Membrane Proteins
Molecular Sequence Data
Mutation
Nuclear Envelope
Nuclear Pore Complex Proteins
Nuclear Proteins
Porins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precipitin Tests

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

alpha Karyopherins

Source

Open in PubMed Open full text

Identifiers

PMID: 8045927
DOI: 10.1083/jcb.126.3.619
PMCID: PMC2120133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8045927-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.PMID 8045927Read ↗

The NUP1 gene encodes an essential component of the yeast nuclear pore complex.Semantic proximity Read ↗

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.Semantic proximity Read ↗

Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure.Semantic proximity Read ↗

ER membrane-bending proteins are necessary for de novo nuclear pore formation.Semantic proximity Read ↗

The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.Semantic proximity Read ↗

Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex.Semantic proximity Read ↗

Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.Semantic proximity Read ↗

Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.Semantic proximity Read ↗

The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function.Semantic proximity Read ↗

Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.Semantic proximity Read ↗

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