Article
Association and linkage analysis of the alpha-adducin gene and blood pressure.
American journal of hypertension - 1 Jun 2000
Bray M S, Li L, Turner S T, Kardia S L, Boerwinkle E
Abstract excerpt
In Milan hypertensive rats, a variant in the alpha-adducin gene has been shown to account for approximately 50% of the interindividual variation in blood pressure levels between these animals and their normotensive counterparts. Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity. On the basis...
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