Article
Mitochondrial DNA and genetic disease.
Essays in biochemistry - 1 Jan 2010
Krishnan Kim J, Turnbull Doug M
Abstract excerpt
From their very beginning to the present day, mitochondria have evolved to become a crucial organelle within the cell. The mitochondrial genome encodes only 37 genes, but its compact structure and minimal redundancy results in mutations on the mitochondrial genome being an important cause of genetic disease. In the present chapter we describe the up-to-date knowledge about mitochondrial DNA structure and...
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