Article
[Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe)].
Der Pathologe - 1 May 2004
Rüschoff J, Roggendorf B, Brasch F, Mathiak M, Aust D E, Plaschke J, Mueller W, Poremba C, Kloor M, Keller G, Muders M, Blasenbreu-Vogt S, Rümmele P, Müller A, Büttner R
Abstract excerpt
Although twin studies indicate that inherited genetic factors contribute to about 35% of colorectal cancers (CRC), the exact genetic background has currently been elucidated in only 5-10% of cases. These comprise several hereditary cancer predisposition syndromes that present with a high number of syn- or metachronous neoplasms within an affected person and/or family. Many of these tumors exhibit typical...
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