Article
B-cell-autonomous somatic mutation deficit following bone marrow transplant.
Blood - 1 Aug 2000
Glas A M, van Montfort E H, Storek J, Green E G, Drissen R P, Bechtold V J, Reilly J Z, Dawson M A, Milner E C
Abstract excerpt
Hematopoietic stem cell transplantation is characterized by a prolonged period of humoral immunodeficiency. We have previously shown that the deficiencies are probably not due to the failure to utilize the appropriate V regions in the pre-immune repertoire. However, a striking observation, which correlated with the absence of immunoglobulin IgD(-) cells and was consistent with a defect in antigen-driven...
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