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Article

Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.

The Journal of biological chemistry - 12 Mar 2004

Lee Mi-Rha, Kim Soo-Hyun, Cho Hyun-Ju, Lee Kun-Yeong, Moon Ae Ran, Jeong Hye Gwang, Lee Jung-Sup, Hyun Jin-Won, Chung Myung-Hee, You Ho Jin

Abstract excerpt

A human 8-oxoguanine-DNA glycosylase (hOGG1) is the main enzyme that repairs 8-oxoG, which is a critical mutagenic lesion. There is a great deal of interest in the up- or down-regulation of OGG1 expression after DNA damage. In this study, we investigated the effect of a DNA-alkylating agent, methylmethane sulfonate (MMS), on hOGG1 expression level and found that MMS treatment resulted in an increase in the...

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Source

Identifiers

PMID: 14688259
DOI: 10.1074/jbc.M311132200

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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