Article
Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling.
Molecular pharmacology - 1 Aug 2000
Koch T, Kroslak T, Averbeck M, Mayer P, Schröder H, Raulf E, Höllt V
Abstract excerpt
The decrease in mu-opioid receptor activity after chronic agonist exposure (1 microM [D-Ala(2),N-MePhe(4),Gly-ol(5)]-enkephalin) is largely due to kinase-mediated phosphorylation of intracellular receptor domains. We have recently shown that the substitution of two putative Ca(2+)/calmodulin-dependent protein kinase II (CaMK II) phosphorylation sites, S261 and S266, by alanines in the third intracellular loop of...
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