Article
Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2000
Jordan M A, Silveira P A, Shepherd D P, Chu C, Kinder S J, Chen J, Palmisano L J, Poulton L D, Baxter A G
Abstract excerpt
Systemic lupus erythematosus induced by Mycobacterium bovis in diabetes-prone nonobese diabetic mice was mapped in a backcross to the BALB/c strain. The subphenotypes-hemolytic anemia, antinuclear autoantibodies, and glomerular immune complex deposition-did not cosegregate, and linkage analysis for each trait was performed independently. Hemolytic anemia mapped to two loci: Bah1 at the MHC on chromosome 17 and...
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