PCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects.

doi:10.2174/1386207003331607

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Article

PCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects.

Combinatorial chemistry & high throughput screening - 1 Jun 2000

Miterski B, Krüger R, Wintermeyer P, Epplen J T

Abstract excerpt

A simple and fast method with high reliability is necessary for the identification of mutations, polymorphisms and sequence variants (MPSV) within many genes and many samples, e.g. for clarifying the genetic background of individuals with multifactorial diseases. Here we review our experience with the polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP) analysis to identify MPSV in a...

Topics

DNA Mutational Analysis
Electrophoresis
Genetic Variation
Humans
Multiple Sclerosis
NF-kappa B
Parkinson Disease
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 10903380
DOI: 10.2174/1386207003331607

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