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Article

Animal Models of Interferon Signature Positive Lupus

5 Jun 2015

Abstract excerpt

Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor-driven interferon production. In contrast, pristane-induced lupus exhibits a prominent TLR7-dependent interferon...

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PMID: 26097482
DOI: 10.3389/fimmu.2015.00291

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