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Article

Role of the proteasome in Alzheimer's disease.

Biochimica et biophysica acta - 26 Jul 2000

Checler F, da Costa C A, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P

Abstract excerpt

The proteasome is a multicatalytic complex involved in the degradation of polyubiquitinated proteins. Here we review the clues of a possible involvement of the proteasome in Alzheimer's disease neuropathology. Thus, we discuss the fact that the proteasome modulates the intracellular concentrations of presenilins 1 and 2. These two proteins, when mutated, appear responsible for most of early onset forms of...

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PMID: 10899438
DOI: 10.1016/s0925-4439(00)00039-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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