Hepatitis C virus genotypes and quasispecies.

doi:10.1016/s0002-9343(99)00376-9

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Article

Hepatitis C virus genotypes and quasispecies.

The American journal of medicine - 27 Dec 1999

Davis G L

Abstract excerpt

Genetic heterogeneity is a hallmark of the hepatitis C virus, as a result largely of the infidelity of viral RNA-dependent RNA polymerase. Random nucleotide substitutions are introduced at a very high rate. The existence of genotypes was confirmed by statistical and mathematical techniques, and the relation of the genotypes to each other has been determined. There are six major genotypes, each with multiple...

Topics

Genome, Viral
Genotype
Hepacivirus
Hepatitis C
Humans
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 10653451
DOI: 10.1016/s0002-9343(99)00376-9

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