Article
Apolipoprotein E2 (Lys146-->Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2000
de Beer F, van Dijk K W, Jong M C, van Vark L C, van der Zee A, Hofker M H, Fallaux F J, Hoeben R C, Smelt A H, Havekes L M
Abstract excerpt
The apolipoprotein E2 (Lys146-->Gln) variant is associated with a dominant form of familial dysbetalipoproteinemia. Heterozygous carriers of this variant have elevated levels of plasma triglycerides, cholesterol, and apolipoprotein E (apoE). It was hypothesized that the high amounts of triglycerides in the very low density lipoprotein (VLDL) fraction are due to a disturbed lipolysis of VLDL. To test this...
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