Article
Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lys146-->Gln) are inefficiently converted to cholesterol-rich lipoproteins.
Atherosclerosis - 1 Aug 1994
Mulder M, van der Boom H, de Knijff P, Braam C, van den Maagdenberg A, Leuven J A, Havekes L M
Abstract excerpt
The APOE*2(Lys146-->Gln) allele behaves like a dominant trait in the expression of familial dysbetalipoproteinemia (FD) (Smit et al., J. Lipid Res. 1990; 31: 45-53). FD patients carrying the APOE*2(Lys146-->Gln) allele exhibit less elevated cholesterol to triglyceride ratios in the d < 1.019 g/ml lipoprotein density fraction as compared to classical FD patients displaying homozygosity for the APOE*2(Arg158-->Cys)...
Topics
- Alleles
- Animals
- Apolipoprotein E2
- Apolipoproteins E
- Binding, Competitive
- Cholesterol
- Genotype
- Heterozygote
- Humans
- Hyperlipoproteinemia Type III
- Lipoproteins