Article
Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers.
The Journal of clinical investigation - 1 Sept 1994
de Knijff P, van den Maagdenberg A M, Boomsma D I, Stalenhoef A F, Smelt A H, Kastelein J J, Marais A D, Frants R R, Havekes L M
Abstract excerpt
Genetic and biochemical studies were carried out in 96 relatives of six independently ascertained probands with familial dysbetalipoproteinemia (FD) carrying the APOE*2 (Lys146-->Gln) allele. Compared to noncarriers, the 40 heterozygous APOE*2 (Lys146-->Gln) allele carriers exhibited markedly inc...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Amino Acid Sequence
- Apolipoprotein E2
- Apolipoproteins E
- Base Sequence
- Child
- DNA Primers
- Female
- Gene Expression
- Genetic Carrier Screening
- Glutamine