Article
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28.
Nature genetics - 1 Jul 2000
Taillon-Miller P, Bauer-Sardiña I, Saccone N L, Putzel J, Laitinen T, Cao A, Kere J, Pilia G, Rice J P, Kwok P Y
Abstract excerpt
Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in the human genome. Population genetic theory suggests that LD is determined by the age of the markers, population history, recombination rate, selection and genetic drift. Despite the uncertainties in determining the relative contributions of these factors, some groups have argued that LD is a simple function of distance...
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