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Regions of low single-nucleotide polymorphism incidence in human and orangutan xq: deserts and recent coalescences.

Genomics - 1 Jan 2001

Miller R D, Taillon-Miller P, Kwok P Y

Abstract excerpt

While scanning for single-nucleotide polymorphisms (SNPs) in the human Xq25-q28 region of CEPH families, we found six long "deserts" of low SNP incidence representing 28% of the investigated genome. One was 1.66 Mb in length. To determine whether these SNP deserts were due to reduced input of mutations or to recent coalescent events such as bottlenecks or selective sweeps, comparative sequence was determined from...

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PMID: 11161800
DOI: 10.1006/geno.2000.6417

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