Article
X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations.
European journal of human genetics : EJHG - 1 Apr 2005
Laan Maris, Wiebe Victor, Khusnutdinova Elza, Remm Maido, Pääbo Svante
Abstract excerpt
Linkage disequilibrium (LD) structure is still unpredictable because the interplay of regional recombination rate and demographic history is poorly understood. We have compared the distribution of LD across two genomic regions differing in crossing-over activity -- Xq13 (0.166 cM/Mb) and Xp22 (1.3 cM/Mb) -- in 15 Eurasian populations. Demographic events predicted to increase the LD level -- genetic drift,...
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