Article
Patterns of linkage disequilibrium between SNPs in a Sardinian population isolate and the selection of markers for association studies.
Human heredity - 1 Jan 2008
Angius Andrea, Hyland Fiona C L, Persico Ivana, Pirastu Nicola, Woodage Trevor, Pirastu Mario, De la Vega Francisco M
Abstract excerpt
OBJECTIVE: In isolated populations, 'background' linkage disequilibrium (LD) has been shown to extend over large genetic distances. This and their reduced environmental and genetic heterogeneity has stimulated interest in their potential for association mapping. We compared LD unit map distances with pair-wise measurements of LD in a dense single nucleotide polymorphism (SNP) set. METHODS: We genotyped 771 SNPs...
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