Article
Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Subramanian Ravi P, Geraghty Robert J
Abstract excerpt
Virus-induced membrane fusion can be subdivided into three phases defined by studies of class I and class II fusion proteins. During Phase I, two membranes are brought into close apposition. Phase II marks the mixing of the outer membrane leaflets leading to formation of a hemifusion intermediate...
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