Article
Functional independence of the two cysteine-rich activation domains in the yeast Mac1 transcription factor.
The Journal of biological chemistry - 22 Sept 2000
Keller G, Gross C, Kelleher M, Winge D R
Abstract excerpt
Mac1 is a transcriptional activator whose activity is inhibited by copper ions. Mutagenesis studies were carried out to map residues important in the copper inhibition of Mac1 activity. Seven new missense mutations were identified that resulted in copper-independent Mac1 transcriptional activation. All seven mutations were clustered in one of two C-terminal cysteine-rich motifs, designated the C1 motif. All but...
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